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TISSUE OPTICS AND MICROCIRCULATION IMAGING

TOMI

was created as a core unit of the National Biophotonics and Imaging Platform Ireland ( NBIPI); the mission of the TOMI laboratory is to promote better healthcare through research and advancements of biophotonics technology.  Our aim is to develop inexpensive, point-of-care tools which will reduce the incidence and mortality of diseases of the microcirculation and cancer via early detection.

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BIGSS 2016 Announced - September 5th to 9th - Ballyvaughan

The lineup and venue for the Biophotonics and Imaging Graduate Summer School (BIGSS 2016) has been announced. This year the summer school will be held in the picturesque Irish village of Ballyvaughan, Co. Clare. Ballyvaughan boasts stunning views of Galway Bay and the Burren. This year the lectures will be:

• Colin Sheppard, Istituto Italiano di Tecnologia Genoa (Fundamentals of Microscopy)
• Kishan Dholakia, St. Andrews (Light sheet, SIM, Raman, complex media (e.g. MM fibres) and beam shaping (Bessel, structured, Airy))
• Igor Meglinski, University of Oulu and Steve Jacques, Oregon Health and Science University (Tissue Optics)
• Adrian Podoleanu, University of Kent (OCT)
• Irina Larina, Baylor College of Medicine (Functional OCT and embryonic development in 4D)
• David Boas, Harvard University (Neurophotonics and Functional optical imaging)
• Matt O’Donnell, University of Washington (Fundamentals of Photoacoustic Imaging)
• Andreas Mandelis, University of Toronto (Time- and frequency domain PA course from the instrumentation perspective along with an introduction to photothermal (thermophotonic) biomedical imaging.

In addition to this hands on training will be provided in Photoacoustic Imaging, Optical Coherence Tomography, Lightsheet imaging and MicroCT.

For further information, please email bigss2016gmail.com.

For more information visit BIGSS '16.

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TOMI GROUP DEVELOPS NANOSENSITIVE OCT

The TOMI group has recently developed a novel label-free depth resolved sensing technique based on optical coherence tomography (OCT) to detect structural changes at the nanoscale, dramatically improving the sensitivity.

To demonstrate this new technique, OCT images of a sample consisting of two layers of polystyrene nanospheres of sizes 614±18 nm and 644±20 nm (mean ± standard deviation) were taken. These layers of nanosphere aggregates have sizes well beyond the resolution limit of the OCT system and so the mean difference between them of 30nm cannot be detected. But the nsOCT approach permits us to visualize such difference as a difference in corresponding spatial periods. By selecting points in each layer and looking at the position of the maximum in the axial spatial period profiles for these points, it is seen that this maximum is shifted to larger spatial periods corresponding to larger dominant sizes of structure for the layer with the larger nanospheres. Thus we can tell that the sizes of the axial structure in one layer are larger than in the other and so it is possible to clearly distinguish the two layers with different nanostructures.

The ability of nsOCT to probe human skin in vivo has also been shown and we expect that the technique could be applicable in early detection and treatment of disease.

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We optimise optical methods through our numerous research and medical collaborations both at home and around the world. For further details of the individual projects, please refer to the staff and student web pages or visit our group publications page.  The content aims to introduce you to our group, and the work carried out by Professor Martin J. Leahy's group, bringing you the most up to date information about our activities and findings.  Please feel free to submit any comments about our site, or work - we welcome all input.

 " If I have seen farther than others, it is by standing on the shoulders of giants." - Sir Isaac Newton

 

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