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BIGSS Programme Outline

Steve Jacques (University of Washington): Tissue Optics and Laser-Tissue Interactions

Steven Jacques

Origins of optical properties; Measurements of optical properties - lookup tables; Monte Carlo simulations; Coupling tissue optics into modelling of photochemical, photothermal and photomechanical effects. 

Laura Waller (Berkeley): Computational Imaging and contrast mechanisms

Laura Waller

Basic background concepts: imaging, point spread functions, resolution, contrast mechanisms. Imaging and scanning microscopes. Computational methods.

Martin Booth (Oxford University): Advanced Microscopy

Martin Booth Wide-field sectioning methods. Super-resolution microscopy (single molecule, structured illumination, STED). Fluorescence microscopy. Confocal and multiphoton microscopy. Aberrations and adaptive optics. Imaging through scattering media.

David Sampson (University of Surrey): Optical Coherence Tomography (OCT)

‌David Sampson Motivating medical microscopy, tissue optics basics, OCT basic principles, OCT image characteristics, OCT extensions – parametric imaging, angiography, elastography, birefringence, examples of clinical applications of OCT: burns, airways – sleep apnoea, asthma, COPD, breast cancer.

Caroline Boudoux (University of Montreal): Endoscopy

‌Caroline Boudoux Instrumentation for in vivo imaging. Fibre types (single-mode, multimode, double-clad, photonic crystals and fiber bundles), couplers, scanners, and detection schemes. Challenges associated with handheld, laparoscopic and endoscopic applications of spectroscopy, OCT, confocal, Raman and nonlinear microscopy.

Sarah Bohndiek (University of Cambridge): Photoacoustics

Sarah Bohndiek A historical perspective; Basic principles of photoacoustic signal generation, Imaging instrumentation: microscopy and tomography; Basic principles of image formation and processing; Multi-modal combinations; Biological and translational applications.

Arjun G. Yodh (University of Pennsylvania): Brain Neurophotonics

Arjun G. Yodh Diffuse optics theory and experimental methodology for measurement of brain tissue scattering, chromophore concentrations, blood flow and, in combination or with other techniques, for measurement of cerebral oxygen metabolism, autoregulation, resting-state networks, and other biomarkers. Selected optical microscopies in the context of neuroimaging. Pre-clinical and clinical examples.   

Brian Wilson (University of Toronto): Principles and Clinical Translation of Light- and Nano-Based Therapeutics

Brian Wilson Phototherapeutics, primarily photodynamic and photothermal. Optical spectroscopies and imaging for intervention guidance, particularly surgery. Phototherapeutics and interventional guidance using optically-active nanoparticles.