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Research interest is the development of new optical methods and tools, such as microscopic imaging and measuring techniques (holographic, interference, polarization, spectral, photoacoustic, etc.) for biomedical and other applications. A significant contribution has resulted in the creation of new optical microscopy methods and techniques for imaging, nondestructive testing, diagnostic and its application to different samples, including biomedical samples and human beings in vivo. |
Selected patents:
- S.A. Alexandrov, T.R. Hillman, T. Gutzler, and D.D. Sampson, “Methods for optical microscopy” International (PCT) patent PCT/AU2007/001423.
- S.A. Alexandrov, M.M. Loiko V.C. Zabarovski, A.P. Shkadarevich, “Device for creation of the moiré pattern” Patent of Republic of Belarus N 3525, 2000.
- S.A. Alexandrov, V.C. Zabarovski, M.M. Loiko, A.P. Shkadarevich, “Method for investigation of the surface relief of a human body” Patent of Republic of Belarus N 3479, 2000.
- S.A. Alexandrov, I.V. Chernyh, “Device for determination of the refractive index and thickness” Patent of Republic of Belarus N 2444, 1998. Euroasian Patent N 000367, 1999.
- S. Alexandrov, H. M. Subhash, A. Zam and M. Leahy “An OCT Inspection System”, NAT129/P/EP, Europe Patent WO/2015/052232 Issued Apr 16, 2015. Priority date October 11, 2013
Selected publications:
- S. Alexandrov, J. McGrath, H. Subhash, F. Boccafoschi, C. Giannini and Martin Leahy, “Novel approach for label free super-resolution imaging in far field”.
Nat. Sci. Rep. 3rd of September 2015, 13274.
http://www.nature.com/articles/srep13274
- S. Alexandrov, H. M. Subhash, and M. Leahy, “Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures”.
Quantum Electronics 2014, v.44, N7, pp.657-653
- S. Alexandrov, H. M. Subhash, A. Zam and M. Leahy, “Nano-sensitive optical coherence tomography”,
Nanoscale 2014. v.6, pp.3545-3549.
- Y. Liu, S. Uttam, S. Alexandrov, R. K Bista, “Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer”,
BMC Biophysic, 2014.
http://www.biomedcentral.com/content/pdf/2046-1682-7-1.pdf
- S. Uttam, R.K. Bista, K. Staton, S. Alexandrov, S. Choi, C.J. Bakkenist, D.J. Hartman, R.E. Brand, and Y. Liu, “Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation”,
Biomedical Optics Express 2013, v.4 N4, pp.596-613.
http://www.opticsinfobase.org/boe/abstract.cfm?uri="boe-4-4-596
- S. Uttam, S. Alexandrov, R. K. Bista, and Y. Liu, “Tomographic imaging via spectral encoding of spatial frequency”,
Optics Express 2013, v. 21, N6, pp. 7488–7504.
http://www.opticsinfobase.org/oe/abstract.cfm?uri="oe-21-6-7488
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S.A. Alexandrov, S. Uttam, R.K. Bista, K. Staton and Y. Liu, “Spectral encoding of spatial frequency approach for characterization of nanoscale structures”, Appl. Phys. Lett. 2012, v.101, 033702.
http://apl.aip.org/resource/1/applab/v101/i3/p033702_s1
- S. A. Alexandrov, S. Uttam, R. K. Bista, Chengquan Zhao and Y. Liu, “Real-time quantitative visualization of 3D structural information”,
Optics Express 2012, v.20, N8, pp. 9203-9214.
http://www.opticsinfobase.org/oe/abstract.cfm?uri="oe-20-8-9203.
- S. A. Alexandrov, S. Uttam, R. K. Bista, and Y. Liu, “Spectral contrast imaging microscopy”, Optics Letters 2011, v.36, N17, pp.3323-3325.
http://www.opticsinfobase.org/ol/abstract.cfm?uri="ol-36-17-3323.
- T. Gutzler, T.R. Hillman, S.A. Alexandrov, D.D. Sampson, “Three-dimensional depth-resolved and extended-resolution micro-particle characterization by holographic light scattering spectroscopy” Optics Express 2010, v18, N24, pp.25116-25126.
http://www.opticsinfobase.org/oe/abstract.cfm?uri="oe-18-24-25116.
- T. Gutzler, T.R. Hillman, S.A. Alexandrov, D.D. Sampson, “Coherent aperture-synthesis wide-field high-resolution holographic microscopy of biological tissue” Optics Letters 2010, v.35, N8, pp.1136-1138.
http://www.opticsinfobase.org/ol/abstract.cfm?uri="ol-35-8-1136.
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T.R. Hillman, T. Gutzler, S.A. Alexandrov, and D.D. Sampson, “High–resolution, wide-field object reconstruction with synthetic aperture Fourier holographic optical microscopy” Optics Express. 2009, v.17, N10, pp. 7873-7892.
http://www.opticsinfobase.org/oe/abstract.cfm?uri="oe-17-10-7873.
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S.G. Adie, B.F. Kennedy, S.A. Alexandrov, J.J. Armstrong, D.D. Sampson, “Audio frequency optical coherence elastography” Phys. Med. Biol. 2009, v.54, pp. 3129-3139.
http://iopscience.iop.org/0031-9155/54/10/011
- S. A. Alexandrov, D. D. Sampson, “Spatial information transmission beyond a system’s diffraction limit using optical spectral encoding of spatial frequency”
J. Opt. A: Pure and Appl. Opt. 2008, v.10, N2, 025304.
http://iopscience.iop.org/1464-4258/10/2/025304.
- S.A. Alexandrov, T.R. Hillman, T. Gutzler, and D.D. Sampson, “Digital Fourier Holography Enables Wide-Field, Superresolved, Microscopic Characterization”
Optics & Photonics News, December 2007, v.18, N12, Microscopy, p. 29.
- T.R. Hillman, S.A. Alexandrov, T. Gutzler, and D.D. Sampson, “Microscopic particle discrimination using spatially-resolved Fourier-holographic light scattering angular spectroscopy”
Optics Express 2006, v.14, N23, pp. 11089-11102 (
http://oe.osa.org/abstract.cfm?URI="oe-14-23-11088, video clip from this paper has been presented on the cover page of the journal).
- S.A. Alexandrov, T.R. Hillman, T. Gutzler, and D.D. Sampson, “Synthetic aperture Fourier holographic optical microscopy” Phys. Rev. Lett. 2006, v. 97, 168102.
http://prl.aps.org/abstract/PRL/v97/i16/e168102. Also was selected for inclusion in a meta-journal for important developments in biology: Virtual J. of Biol. Phys. Research, v.12, N9, 2006. (cited by 91 times according to Google Scholar).
- S.A. Alexandrov, T.R. Hillman and D.D. Sampson, “Spatially resolved Fourier holographic light scattering angular spectroscopy”
Optics Letters, 2005, v.30, N24, pp. 3305-3307.
http://www.opticsinfobase.org/ol/abstract.cfm?uri="ol-30-24-3305. Also was selected for inclusion in a meta-journal for important developments in biology: Virtual J. of Biol. Phys. Research, v.11, N1, 2006.
- A.V. Zvyagin, K.K.M.B.D. Silva, S.A. Alexandrov, T.R. Hillman, J.J. Armstrong, T. Tsuzuki and D.D. Sampson, “Refractive index tomography of turbid media by bifocal optical coherence refractometry”
Optics Express 2003, v.11, N25, pp.3503-3517 (
http://www.opticsexpress.org/abstract.cfm?URI="OPEX-11-25-3503
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J.J. Armstrong, M.S. Leigh, I.D. Walton, A.V. Zvyagin, S.A. Alexandrov, S. Schwer, D.R. Hillman, P.R. Eastwood and D.D. Sampson, “In vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography”
Optics Express 2003, v.11, N15, pp.1817-1826 (
http://www.opticsexpress.org/abstract.cfm?URI="OPEX-11-15-1817
- S.A. Alexandrov, A.V. Zvyagin, K.K.M.B.D.Silva, D.D.Sampson, “Bifocal optical coherence refractometry of turbid media”
Optics Letters 2003, v.28, N2, pp.117-119 (
http://www.opticsinfobase.org/ol/abstract.cfm?uri="ol-28-2-117)
- S.A. Alexandrov, I.V. Chernyh, “Vibration-proof interferometer for studying transparent objects”
Journal of Optical Technology, v 68, n 3, pp. 222-224. (A Translation of Opticheskii Zhurnal 2001, v.68, N3, pp.70-73).
- S.A. Alexandrov, I.V. Chernyh, “Interference method for determination of the refractive index and thickness”
Optical Engineering. 2000, v.39, N9, pp. 2480-2486.
- S.A. Alexandrov, “Incoherent method of hologram formation”
Optics and Spectroscopy 1998, v.85, N6, pp.946-949.
- S.A. Alexandrov, “Holographic polarization interferometry”
JEOS A, Pure and Applied Optics 1996, v.5, pp.767-776.
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